Molecular and Basic Mechanisms of Anesthesia

Molecular and Basic Mechanisms of Anesthesia

B.W. Urban & M. Barann (editors)
This book contains condensed papers of the contributions presented at the "Sixth International Conference on Molecular and Basic Mechanisms of Anesthesia", held in Bonn in June 2001. Ascending the hierarchical order of the central nervous system from molecules to intact organisms, the materials have been arranged following the organization of the conference: Molecular Basis of Anesthetic Interactions, Anesthetic Interactions with Ion Channels and Other Proteins, Integration of Anesthetic Actions (In-Vitro) and, finally, In-Vivo-Networks. In addition to insights at the molecular level, exciting results have been obtained from the various in-vitro slice preparations and from in-vivo electrophysiology as well as from in-vivo functional imaging, indicating a much higher level of complexity than originally appreciated.

Contens
M. Barann, K. W. Miller, C. D. Richards, S. H. Roth, B. W. Urban: Preface: Molecular and Basic Mechanisms of Anesthesia
G. S. Bause: Bernard Raymond Fink, M.D., F.F.A.R.C.S. (1914-2000)
1. Molecular Basis of Anesthetic Interactions
1.1 Modelling
J. R. Trudell, E. Bertaccini: Molecular Modelling of Anesthetic Binding Sites in Ligand-Gated Ion Channels
J. S. Johansson, G. A. Manderson: The Effect of Aromatic Amino Acid Side-Chain Structure on Halothane Binding to Four-Helix Bundles
Y. Kaminoh, C. Tashiro, H. Kamaya: The Interaction of Local Anesthetics with the DMPG Membrane
K. Ogli: Halothane Decreases the Viscosity of Bovine Serum Albumin (BSA) Solution
Abstracts
1.2 Molecular Targets
E. A. Barnard: The Range of Channel Structures and Their Potential Sites for Anesthetic Interaction
J. P. Dilger, D. Oustecky, C. J. Tzan: Kinetics Count! Examples Using the Acetylcholine Receptor
E. I. Eger II: What Have We Learned from Nonimmobilizers?
M. Jetzek-Zader, P. Lipfert: Characterisation of Anesthetic Target Sites by Fluorescence: Acridine and Methyl Salicylate Have Anesthetic Properties and Interact with Albumin and Octanol
C. Sandorfy: Towards a Comprehensive Theory of General Anesthesia
Abstracts
2. Anesthetic Interactions with Ion Channels and Other Proteins
2.1 Nicotinic ACh Receptors
H. R. Arias, E. A. McCardy, M. J. Gallagher, M. P. Blanton: A Barbiturate Binding Site in the Nicotinic Acetylcholine Receptor Ion Channel
P. Flood, J. M. Sonner: Behavioral Results of Isoflurane Inhibition of Neuronal Nicotinic Acetylcholine Receptors
P. Friederich, A. Dybek, M. Barann, B. W. Urban: SH-SY5Y cells: A Model for the Study of Pharmacological Action on Human Nicotinic Acetylcholine Receptors of Sympathetic Ganglions
T. Narahashi, J. Z. Yeh, T. Mori, G. L. Aistrup, W. Marszalec, Y. Zuo, X. Zhao: Role of Neuronal Nicotinic Acetylcholine Receptors in the Mechanism of General Anesthesia
T. Narahashi, J. Z. Yeh, G. L. Aistrup, Y. Zuo, W. Marzalec : Modulation of Neuronal Nicotinic Acetylcholine Receptors by Alcohols
R. J. Claycomb, S. A. Forman, D. E. Raines : Inhibition of Alpha4Beta2 Rat Neuronal Nicotinic Acetylcholine Receptors by Nonhalogenated Alkane Anesthetics and Perhalogenated Alkane Nonimmobilizers
I. Wenningmann, D. Demazumder, J. P. Dilger: The Kinetics of Inhibition of Nicotinic Acetylcholine Receptors by Metocurine
Abstracts
2.2 GABAA Receptors
M. H. Akabas, J. Horenstein, D. B. Williams, M. Bali, A. K. Bera: GABA- and Drug-Induced Conformational Changes Detected in the GABAA Receptor Channel-Lining Segments
G. Akk, J. H. Steinbach: Do Barbiturates Affect How GABAA Receptors Open or How They Close?
G. Haeseler, B. Mohammadi, K. Krampfl, M. Leuwer, R. Dengler, S. Piepenbrock, J. Bufler: The Potency of a Phenol Derivative for Direct Activation of Chloride Currents via GABAA Receptors is Related to the Position of Methyl and Isopro